Polysialic acid regulates cell contact-dependent neuronal differentiation of progenitor cells from the subventricular zone
نویسندگان
چکیده
منابع مشابه
Isolation and Differentiation of Neural Stem/Progenitor Cells From Subventricular Zone of One Adult Rat
Introduction: In adult mammalian brain, neural stem cells are isolated from both the dentate gyrus and subventricular zone. This study aimed to isolate neural stem cells from adult rat subventricular zone and differentiate them into neurons and astrocytes. Methods: In this study, the whole brain was removed after full anesthesia and creating cervical dislocation. Under a microscope, subv...
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BACKGROUND Gap junction communication has been shown in glial and neuronal cells and it is thought they mediate inter- and intra-cellular communication. Connexin 36 (Cx36) is expressed extensively in the developing brain, with levels peaking at P14 after which its levels fall and its expression becomes entirely neuronal. These and other data have led to the hypothesis that Cx36 may direct neuro...
متن کاملDynamin-related protein 1 controls the migration and neuronal differentiation of subventricular zone-derived neural progenitor cells
Mitochondria are important in many essential cellular functions, including energy production, calcium homeostasis, and apoptosis. The organelles are scattered throughout the cytoplasm, but their distribution can be altered in response to local energy demands, such as cell division and neuronal maturation. Mitochondrial distribution is closely associated with mitochondrial fission, and blocking ...
متن کاملThe Role of Polysialic Acid in Migration of Olfactory Bulb Interneuron Precursors in the Subventricular Zone
Transplantation studies have been used to show that tangential migration of olfactory bulb interneuron precursors is retarded in NCAM-mutant mice, and that this defect reflects loss of NCAM polysialic acid (PSA). In contrast, radial migration of cells within the bulb did not require PSA. Reciprocal transplantations between wild-type and mutant mice have revealed that the mutation affects the in...
متن کاملTranscription factor protein expression patterns by neural or neuronal progenitor cells of adult monkey subventricular zone.
The anterior subventricular zone of the adult mammalian brain contains progenitor cells which are upregulated after cerebral ischemia. We have previously reported that while a part of the progenitors residing in adult monkey anterior subventricular zone travels to the olfactory bulb, many of these cells sustain location in the anterior subventricular zone for months after injury, exhibiting a p...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2004
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.20094